Description | Dr. Simpson's research interests involve the application of analytical chemistry to the development of techniques for assessment of exposure to toxic chemicals, and the subsequent application of those techniques to investigate occupational and environmental exposures. He is particularly interested in the development of analytical methodology to measure xenobiotics and their metabolites or transformation products in biological samples (biomarkers). In support of these efforts, he conducts studies to develop sampling and analysis methods for environmental samples, to provide accurate external exposure measures to validate the biomarkers. He is also interested in applying biomarker techniques in the field of chemical carcinogenesis – to provide new insights into the role of metabolic phenotype and environmental factors in modifying cancer risk. |
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