Description | Thomas Jhou, PhD Assistant Professor of Neuroscience Medical University of South Carolina Individual Differences in Aversive Effects of Cocaine: their Heritability, Molecular Mechanisms, and Influences on Drug-Seeking Cocaine has well-known rewarding effects, but its aversive effects are also prominent and less well understood. We have recently found evidence that conditioned avoidance responses to cocaine vary greatly between individual rats, are predictive of drug-seeking, and are strongly heritable. These differences also involve differences in receptor signaling in the rostromedial tegmental nucleus (RMTg), a major GABAergic afferent to midbrain dopamine neurons. This free lecture is made possible by a generous endowment from Professor Roger B. Loucks. |
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