Endolysosomal dysfunction as a therapeutic target for Alzheimer’s disease: Insights from hiPSC models Jessica Young, PhD
Associate Professor
Department of Laboratory Medicine & Pathology
Institute for Stem Cell and Regenerative Medicine
University of Washington Why Attend this Seminar? Developing effective therapies for Alzheimer’s disease (AD) is highly challenging. Using human induced pluripotent stem cells (hiPSCs), the Young lab derives neurons and glia to study early cellular pathways that go awry in AD in order to move target development away from its focus on end-stage pathology. In this project, we will describe our on-going studies on how endosomal and lysosomal networks are impaired in AD, with a focus on a newly emerging Alzheimer’s risk gene SORL1. We will highlighted functional studies performed in hiPSC-derived neurons and microglia to dissect how dysfunction in endolysosomal trafficking specifically affects these different cell types. We will also present data showing that small molecules that enhance the endolysosomal pathway show promise in ameliorating some of AD’s earliest cytopathologies. Meeting ID: 930 4620 8772
Passcode: PATH520 |