| Description | Analyzing, predicting, and engineering adaptive immune responses
Abstract
The ability to predict and correspondingly manipulate an adaptive immune response would be highly valuable for biotechnology and medicine. To achieve this requires a greater molecular understanding of adaptive immunity. Recent advances in high-throughput antibody repertoire sequencing are enabling highly quantitative analysis of adaptive immune responses. This increased immunological insight has been applied to fields as varied as immune cell development, immunodiagnostics, vaccine development, cancer immunotherapy, and antibody drug discovery. Here I will present, the computational and experimental methods my group has developed in antibody sequencing and their associated applications. For, example we have recently developed a comprehensive error and bias correction method that enables highly accurate sequencing. We are also applying machine-learning approaches that enable prediction of the immune status of individual antibody clones. Finally, I will also highlight recent work in our group aimed towards engineering immune cells with genome editing technology, for applications in antibody engineering and cellular immunotherapy. Bio
Sai Reddy is a tenure-track Assistant Professor (since 02.2012) in the Dept. of Biosystems Science & Engineering, ETH Zurich, Switzerland. His research group uses methods in systems and synthetic biology to study and manipulate immune responses for applications in biotechnology, vaccination, and immunotherapy. Sai Reddy holds B.S. (2003) and M.S. (2004) in Biomedical Engineering from Northwestern University (Evanston, IL, USA). He completed his Ph.D. thesis at Ecolé Polytechnique Féderale de Lausanne (EPFL, Switzerland) in Bioengineering and Biotechnology (2008). Sai Reddy did post-doctoral research at the University of Texas, Austin (2008-2011). Molecular Engineering and Sciences Seminar Series This weekly seminar brings together students, faculty and invited guests from various disciplines across campus to explore current trends in molecular engineering and nanotechnology. It is a forum for active interdisciplinary discussions. These talks are open to the public and attract a diverse audience of students and faculty. |
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