| Description | Molecular Engineering and Sciences Seminar Series
New Single Cell Methods for Oncology and Immuno-oncology
Abstract: In this talk I will discuss new algorithms and analytical methods associated with single cell analysis, with an emphasis on capturing and analyzing multiple levels of information (i.e. multi-omic analysis) from the same single cells. In one application, I will discuss how continuous cellular trajectories can be extracted from a kinetic series of snapshots, each of which provides a view of the cell-state space sampled by a cell population at a given point in time. The approach will be applied towards the study of the short-time development of drug resistance in patient-derived melanoma models against targeted inhibitors. In a second application, I will discuss how integrated metabalomic, lipidomic, and transcriptomic single cell assays can be integrated to begin developing causal relationships across analyte classes. Finally, I will discuss large library approaches designed for sampling and single cell characterization of antigen-specific T cell populations. --- This weekly seminar brings together students, faculty and invited guests from various disciplines across campus to explore current trends in molecular engineering and nanotechnology. It is a forum for active interdisciplinary discussions. These talks are open to the public and attract a diverse audience of students and faculty. |
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