Description | Molecular Engineering and Sciences Seminar Series Bioinspired Synthetic Nanobiomaterials for Immunotherapy Abstract: Self-assembled nanobiomaterials that are engineered to achieve specific biodistributions and mechanisms of degradation hold great promise for controlled stimulation of the immune system. Taking advantage of the morphological flexibility of self-assembled systems, we aim to mimic various structures and biochemical mechanisms of pathogens to enhance cell-selective intracellular delivery and treatment efficacy during immunotherapy. We specifically approach this by synthesizing, assembling and optimizing in vitro and in vivo a range of nanostructures loaded with strategically selected combinations of immunostimulants to achieve controlled activation or suppression of the immune system. Here, I will present some of our ongoing work in the area of nanobiomaterials development as well as recent applications of our materials for the controlled modulation of inflammatory cells during cell/organ transplantation, vaccination and treatment of atherosclerosis and infectious diseases. This weekly seminar brings together students, faculty and invited guests from various disciplines across campus to explore current trends in molecular engineering and nanotechnology. It is a forum for active interdisciplinary discussions. These talks are open to the public and attract a diverse audience of students and faculty. |
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