| Description | The Department of Bioengineering presents the Allan S. Hoffman Lecture. Speaker: Kristi S. Anseth, Distinguished Professor of Chemical and Biological Engineering at the University of Colorado. The Anseth group focuses on the development of biomaterial matrices that can serve as advanced culture systems or in vivo delivery systems for primary cells. Here, our group has focused on the development of photochemical reactions to create tunable cell-laden matrices, for example, the thiol-ene photo-click reaction and complementary photo-clip reactions to introduce and remove biological signals from a complex milieu. This talk will illustrate how we leverage these and other reversible chemistries to create biologically responsive hydrogel matrices, and employ them to study the effects of matricellular signaling on diverse cellular functions and processes. More recently, we have integrated photodegradable linkers into hydrogels and used these spatiotemporal controlled reactions to direct the growth and differentiation of stem cells into intestinal organoids. |
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