IMPORTANT NOTE: 1/4/22 Pathology Grand Rounds will be ONLINE ONLY.
"Maladaptive Microcircuits: Interrogating Selective Vulnerability after Traumatic Brain Injury"
Amber Nolan, MD, PhD Assistant Professor, Division of Neurology Department of Laboratory Medicine & Pathology University of Washington Objectives: - Review the chronic effects and common mechanisms of injury associated with traumatic brain injury (TBI).
- Describe models of TBI.
- Review the cortical microcircuit.
- Evaluate function and selective vulnerability after TBI
Speaker disclosures: Dr. Amber Nolan has NOT had any financial relationships with any ineligible entities within the past 24 months. Why Attend? Traumatic brain injury is a frequent cause of disability in this country, with >30-50% of patients experiencing chronic to progressive neurologic deficits including aberrant changes in social behavior, anxiety, attention, memory, task switching and mental flexibility- behaviors associated with neuronal circuits in the prefrontal cortex. Yet little is known about the maladaptive reorganization that occurs after trauma in these cortical networks, limiting ability to develop appropriate therapeutics; furthermore, the role of selective vulnerability and neuroinflammation in contributing to prolonged injury is not established. This talk will examine how the function of cortical microcircuits change chronically after TBI and begin to discuss the role of neuroinflammation in contributing to maladaptive functional changes. Meeting ID: 931 1873 4050
Passcode: PGR2122You must sign-in on the following form to receive CME credit. Sign-in online: https://forms.gle/W2oE8d3MYbnyTDe58
Planning Committee Disclosure: The following members have not had any financial relationships with any ineligible entities in the past 24 months: Drs. Rebecca Alvarez, Eleanor Chen, Lisa Koch, Jose Mantilla, Elizabeth Parker, Maria Tretiakova, Larry True, James Malleis, and Trent Irwin. The following members disclose financial relations with ineligible entities within the past 24 months: Dr Shreeram Akilesh discloses a financial relationship (speaker honorarium) with GoldfinchBio, Inc.; Dr. Haodong Xu discloses a financial relationship with PathomIQ (consultant). All relevant financial relationships listed have been mitigated.
Grant Acknowledgment: None
CME Accreditation statement: The University of Washington School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The University of Washington School of Medicine designates this live activity for a maximum of 10.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. (Each session is 1.0 credit) |