| Description | UW Pathology Presents “Sex-dimorphism in immune aging: Are we missing half of the picture?"
Bérénice A. Benayoun, PhD
Assistant Professor of Gerontology, Biological Sciences, Biochemistry and Molecular Medicine
University of Southern California Leonard Davis School of Gerontology
Why Attend this Seminar?
The existence of human supercentenarians reveals a surprising predictor for exceptional longevity: being female. Not only are 33 out of 34 living supercentenarians women, women are also more resistant to almost all diseases responsible for morbidity and mortality in the United States. However, sex-driven differences, their molecular underpinning and impact on health remain poorly understood. A key compartment whose activity could be actively modulated by sex-dimorphic mechanisms throughout life is the immune system, whose function declines sharply with aging and may be actively modulated by sex. Indeed, aspects of the immune responses differ between sexes, with a more robust immune response in females and an increased susceptibility to infection in males. In this seminar, we will discuss recent work from the Benayoun lab on how the influence of sex on aging immune cells using functional genomics approaches. We will also discuss how this may be important, in the longer term, as a criteria to improve tailored pro-healthspan strategies in humans.
Meeting ID: 994 1137 3399
Passcode: 5202122 |
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