Spatial Transcriptomics for Clinical-Translational Pathology Research
Shreeram ‘Ram’ Akilesh, MD PhD Associate Professor, Renal Pathology Medical Director, Immunofluorescence Laboratory Director, Digital Spatial Profiling Core Facility Member, Kidney Research Institute Department of Laboratory Medicine & Pathology University of Washington Why Attend this Seminar? In recent years, several technologies have been developed to quantify and localize gene expression in tissue sections (collectively referred to as spatial transcriptomics). These methods vary in their chemistry, resolution and compatibility with formalin-fixed paraffin embedded (FFPE) tissues. In this seminar, we will review the strengths and limitations of the major commercial platforms that enable spatial transcriptomics. We will showcase how these methods can be used to study inter- and intra-patient variability in disease pathology. We will also provide examples on how to leverage these approaches to perform clinical-translational pathology research thereby providing a pathway for new laboratory-developed tests. Meeting ID: 930 4620 8772
Passcode: PATH520 |