Computational Analysis of Aortic Hemodynamics with Application to Type-B Dissections
Abstract: Type-B Aortic Dissection (TBAD) is a life-threatening condition in which a tear in the descending aorta creates a true lumen and a false lumen (FL), whose progressive expansion significantly worsens patient prognosis. Despite advances in imaging-based analysis, reliable predictive biomarkers for FL growth remain elusive. This thesis presents a high-fidelity computational fluid dynamics (CFD) framework employing Large-Eddy Simulations (LES) to model patient-specific turbulent blood flow in TBAD with high resolution. By capturing complex transitional and turbulent flow structures inherent to the dissected aorta, LES enables accurate computation of wall shear stress (WSS) and a set of WSS-derived hemodynamic indices. These indices are analyzed alongside morphological features from computed tomography angiography to investigate their association with FL progression, advancing toward robust risk stratification and more personalized treatment strategies for TBAD.
Event Type: Dissertation. Research Area: Defense. Location: MSC E300. Speaker Name: Jiaqi Yang. Speaker Institution: Emory University.
Thursday, April 23, 2026, 9:00 AM – 10:00 AM.