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Pathology Grand Rounds: Robert Ricciotti, MD, PhD - Development of a Convolutional Neural Network Model for Image Analysis at the University of Washington

Robert Ricciotti, MD; Assistant Professor, Anatomic Pathology, Director, Bone & Soft Tissue Pathology Fellowship Program, Department of Laboratory Medicine & Pathology, University of Washington,   Objectives: Describe potential uses for multiple instance learning (MIL) in image analysis. , Describe how k-fold cross validation works. , Identify ways in which MIL may be useful on your own clinical service. Speaker disclosures:  Dr. Robert Ricciotti has NOT had any financial relationships with any ineligible entities within the past 24 months Why Attend? Learn about an image analysis model developed in collaboration with the UW department of computer science and engineering and some of the ways it may be useful in aiding pathologists.  Meeting ID: 983 8715 9855, Passcode: PATHGR,  Attendance tracking instructions: , UW attendees track attendance by TEXT for CME & CE credit: , One-Time: Text your email address to 833-394-7078 for initial set-up. , Weekly: Text code 8818 to 833-394-7078 , Credit must be… Event interval: Single day event. Campus location: UW Medical Center, Wing NE (UMNE). Online Meeting Link: https://washington.zoom.us/j/98387159855?pwd=bzhmRGNjWlM4YkZBYkdmQlluVko0Zz09. Campus room: NE-110k Pathology Conference Room. Accessibility Contact: hsbuild@uw.edu. Event Types: Lectures/Seminars. Target Audience: Faculty, fellows, post-docs, residents, and students. Wednesday, May 1, 2024, 1:30 PM – 2:30 PM. For more info visit dlmp.uw.edu.

Lab Med Clinical Research Conference: Nilasha Sen - Investigating sex differences in mouse models of malaria vaccination using acute, reversible hormone manipulation

Laboratory Medicine Clinical Research Conference (LM510) is held most Wednesdays during term at 2:30 PM, and provides a forum for students, residents and fellows to present their ongoing research and development work. Topics can include method development and instrument evaluation, clinical research, or basic laboratory research.Meeting ID: 933 7306 7209 Passcode: 510, Sign-in is required to receive Continuing Education (CE) credit and for students registered in LabM 510. Sign-In Online: https://forms.gle/CuXdwxCGjDBtqmBAA . Event interval: Ongoing event. Campus location: Magnuson Health Sciences Center Rr (HSRR). Online Meeting Link: https://washington.zoom.us/j/93373067209?pwd=NzUwR3oxUnJ5TU9LS3JWVVlSVmwyZz09. Campus room: RR-134. Accessibility Contact: hsbuild@uw.edu. Event Types: Lectures/Seminars. Event sponsors: Sponsored by the Department of Laboratory Medicine & Pathology. Wednesday, May 1, 2024, 2:30 PM – 3:30 PM.

LabMed Grand Rounds: Leo Yermakov, MD, PhD - DNA Repair Pathways and Subtyping in Advanced Prostate Cancer

Leo Yermakov, MD, PhD, Resident (PGY-3), Department of Laboratory Medicine & Pathology, University of Washington,   Objectives: Discuss the key DNA repair pathways in advanced prostate cancer. , Appreciate the significance of molecular subtyping in prostate cancer management. , Assess the utility of cell-free DNA analysis in advanced prostate cancer, Speaker disclosures:  Dr. Leo Yermakov has NOT had any financial relationships with any ineligible entities within the past 24 months. Live streamed via Zoom*: https://washington.zoom.us/j/96677954374     Attendance tracking instructions: , UW attendees track attendance by TEXT for CME & CE credit: , One-Time: Text your email address to 833-394-7078 for initial set-up. , Weekly: Text code 8815 to 833-394-7078 , Credit must be recorded via text in the 60 minutes before, during, and up to 60 minutes after the activity concludes.  If you miss the texting window, use “CME Dept Assistance Request Form” on www.uwcme.org  or email cme@uw.edu.  Non-UW Attendees… Event interval: Ongoing event. Campus location: Magnuson Health Sciences Center D (HSD). Online Meeting Link: https://washington.zoom.us/j/96677954374. Campus room: HSB Room D-209 (Turner Auditorium). Accessibility Contact: hsbuild@uw.edu. Event Types: Lectures/Seminars. Wednesday, May 1, 2024, 3:30 PM – 4:30 PM. For more info visit dlmp.uw.edu.

Lab Med Clinical Research Conference: Jamie Garrett - TBA

Laboratory Medicine Clinical Research Conference (LM510) is held most Wednesdays during term at 2:30 PM, and provides a forum for students, residents and fellows to present their ongoing research and development work. Topics can include method development and instrument evaluation, clinical research, or basic laboratory research.Meeting ID: 933 7306 7209 Passcode: 510, Sign-in is required to receive Continuing Education (CE) credit and for students registered in LabM 510. Sign-In Online: https://forms.gle/CuXdwxCGjDBtqmBAA . Event interval: Ongoing event. Campus location: Magnuson Health Sciences Center Rr (HSRR). Online Meeting Link: https://washington.zoom.us/j/93373067209?pwd=NzUwR3oxUnJ5TU9LS3JWVVlSVmwyZz09. Campus room: RR-134. Accessibility Contact: hsbuild@uw.edu. Event Types: Lectures/Seminars. Event sponsors: Sponsored by the Department of Laboratory Medicine & Pathology. Wednesday, May 8, 2024, 2:30 PM – 3:30 PM.

LabMed Grand Rounds: Gottfried Schmer Memorial Lecture: Linnie M. Golightly, MD - Colonialism: The Lingering Effects of the Past in the Present

Linnie M. Golightly, MD, Associate Dean of Diversity and Inclusion, Associate Professor of Clinical Medicine, Microbiology & Immunology, Division of Infectious Diseases, Center for Global Health, Weill Cornell Medicine, President, American Society of Tropical Medicine and Hygiene (AS,   Objectives: Define colonialism and its impact on current relationships in global health research, science and medicine. , Describe and give examples of how and why colonialism might affect ones world view. , Consider possibilities of how given the history of colonialism in medical science attendees might change their research and teaching methods and interactions with others in the field. Speaker disclosures:  Dr. Linnie Golightly has NOT had any financial relationships with any ineligible entities within the past 24 months. Live streamed via Zoom*: https://washington.zoom.us/j/96677954374     Attendance tracking instructions: , UW attendees track attendance by TEXT for CME & CE credit: , One-Time: Text your email… Event interval: Ongoing event. Campus location: Magnuson Health Sciences Center D (HSD). Online Meeting Link: https://washington.zoom.us/j/96677954374. Campus room: HSB Room D-209 (Turner Auditorium). Accessibility Contact: hsbuild@uw.edu. Event Types: Lectures/Seminars. Wednesday, May 8, 2024, 3:30 PM – 4:30 PM. For more info visit dlmp.uw.edu.

Lab Med and Pathology Research & Discovery Seminar: Gilad D. Evrony, PhD - High-fidelity DNA sequencing of the single-strand origins of mutations

High-fidelity DNA sequencing of the single-strand origins of mutations Gilad D. Evrony, PhD Assistant Professor, Center for Human Genetics & Genomics NYU Grossman School of Medicine Why Attend this Seminar? Most mutations begin as a change to one of the two strands of the DNA double helix. However, these single-strand DNA changes have not been feasible to profile at single-molecule resolution. We have developed a DNA sequencing technology capable of profiling both single-strand and double-strand DNA changes with single-molecule fidelity. This includes both single-strand mismatches of canonical nucleotides and single-strand cytosine deamination damage. The revealed patterns of single-strand changes provide insight into the origins of mutations in several cancer predisposition syndromes. This work provides an initial framework for creating a catalogue of single-strand DNA damage and repair signatures that explain the known double-strand DNA mutation signatures. Meeting ID: 930 4620 8772 Passcode: PATH520… Event interval: Ongoing event. Campus location: Magnuson Health Sciences Center K (HSK). Online Meeting Link: https://washington.zoom.us/j/93046208772?pwd=Z1hUK2paQkZocG92WDJmUHZkTnZBZz09. Campus room: K-069. Accessibility Contact: hsbuild@uw.edu. Event Types: Lectures/Seminars. Event sponsors: Sponsored by the Department of Laboratory Medicine & Pathology. Target Audience: Faculty, fellows, post-docs, residents, and students. Tuesday, May 14, 2024, 4:00 PM – 5:00 PM.

Lab Med Clinical Research Conference: Suhhyun (Sarah) Kim - SuperCoombs testing in DAT negative hemolytic anemia, a retrospective review

Laboratory Medicine Clinical Research Conference (LM510) is held most Wednesdays during term at 2:30 PM, and provides a forum for students, residents and fellows to present their ongoing research and development work. Topics can include method development and instrument evaluation, clinical research, or basic laboratory research.Meeting ID: 933 7306 7209 Passcode: 510, Sign-in is required to receive Continuing Education (CE) credit and for students registered in LabM 510. Sign-In Online: https://forms.gle/CuXdwxCGjDBtqmBAA . Event interval: Ongoing event. Campus location: Magnuson Health Sciences Center Rr (HSRR). Online Meeting Link: https://washington.zoom.us/j/93373067209?pwd=NzUwR3oxUnJ5TU9LS3JWVVlSVmwyZz09. Campus room: RR-134. Accessibility Contact: hsbuild@uw.edu. Event Types: Lectures/Seminars. Event sponsors: Sponsored by the Department of Laboratory Medicine & Pathology. Wednesday, May 15, 2024, 2:30 PM – 3:30 PM.

LabMed Grand Rounds: Jamie Garrett, MD - TBA

SPEAKER NAME,   Objectives: Speaker disclosures:  Live streamed via Zoom*: https://washington.zoom.us/j/96677954374     Attendance tracking instructions: , UW attendees track attendance by TEXT for CME & CE credit: , One-Time: Text your email address to 833-394-7078 for initial set-up. , Weekly: Text code 8815 to 833-394-7078 , Credit must be recorded via text in the 60 minutes before, during, and up to 60 minutes after the activity concludes.  If you miss the texting window, use “CME Dept Assistance Request Form” on www.uwcme.org  or email cme@uw.edu.  Non-UW Attendees & students use this form for credit: https://tinyurl.com/signin-gr, All attendees are asked to complete the evaluation form here: https://tinyurl.com/signin-gr , All attendees are encouraged to sign in in order to provide evaluation feedback for the presenters and to help us track accurate attendance. Thank you! Laboratory Medicine Grand Rounds runs most Wednesdays during term in fall, winter and spring quarters from 3:30 to 4:30 PM… Event interval: Ongoing event. Campus location: Magnuson Health Sciences Center D (HSD). Online Meeting Link: https://washington.zoom.us/j/96677954374. Campus room: HSB Room D-209 (Turner Auditorium). Accessibility Contact: hsbuild@uw.edu. Event Types: Lectures/Seminars. Wednesday, May 15, 2024, 3:30 PM – 4:30 PM. For more info visit dlmp.uw.edu.

Lab Med Clinical Research Conference: Rose Anderson - Neurophysiological Impact of PTSD on the Brain

Laboratory Medicine Clinical Research Conference (LM510) is held most Wednesdays during term at 2:30 PM, and provides a forum for students, residents and fellows to present their ongoing research and development work. Topics can include method development and instrument evaluation, clinical research, or basic laboratory research.Meeting ID: 933 7306 7209 Passcode: 510, Sign-in is required to receive Continuing Education (CE) credit and for students registered in LabM 510. Sign-In Online: https://forms.gle/CuXdwxCGjDBtqmBAA . Event interval: Ongoing event. Campus location: Magnuson Health Sciences Center Rr (HSRR). Online Meeting Link: https://washington.zoom.us/j/93373067209?pwd=NzUwR3oxUnJ5TU9LS3JWVVlSVmwyZz09. Campus room: RR-134. Accessibility Contact: hsbuild@uw.edu. Event Types: Lectures/Seminars. Event sponsors: Sponsored by the Department of Laboratory Medicine & Pathology. Wednesday, May 22, 2024, 2:30 PM – 3:30 PM.

Combined DLMP Grand Rounds: Valerie Fitzhugh, MD - The Unicorns- Considerations for Diversifying Pathology and Laboratory Medicine

Valerie Fitzhugh, MD, Professor and Chair; Pathology, Immunology, & Laboratory Medicine, Rutgers New Jersey Medical School, Professor & Chair; Pathology & Laboratory Medicine, Robert Wood Johnson Medical School, Senior Vice President; Pathology Services, Robert Wood Johnson Barn,   Objectives: Understand the current landscape of underrepresented populations in pathology. , Learn some of the barriers to recruitment in pathology. , Gain understanding from the personal experiences of a pathologist who is underrepresented in medicine to improve relations between all pathologists. Speaker disclosures:  Dr. Valerie Fitzhugh has NOT had any financial relationships with any ineligible entities within the past 24 months. Live streamed via Zoom*: https://washington.zoom.us/j/96677954374     Attendance tracking instructions: , UW attendees track attendance by TEXT for CME & CE credit: , One-Time: Text your email address to 833-394-7078 for initial set-up. , Weekly: Text code 8815 to 833-394-7078 , Credit must… Event interval: Ongoing event. Campus location: Magnuson Health Sciences Center D (HSD). Online Meeting Link: https://washington.zoom.us/j/96677954374. Campus room: HSB Room D-209 (Turner Auditorium). Accessibility Contact: hsbuild@uw.edu. Event Types: Lectures/Seminars. Wednesday, May 22, 2024, 3:30 PM – 4:30 PM. For more info visit dlmp.uw.edu.

Lab Med and Pathology Research & Discovery Seminar: TBA

TITLE SPEAKER Why Attend this Seminar?  Meeting ID: 930 4620 8772 Passcode: PATH520  Sign-In & Evaluation Form Online: https://forms.gle/dfmHNTVdxH9Dbwbt9 , Sign-in is required for students registered in PATH 520. All other attendees are encouraged to track attendance and complete an evaluation of the presentation. Event interval: Ongoing event. Campus location: Magnuson Health Sciences Center K (HSK). Online Meeting Link: https://washington.zoom.us/j/93046208772?pwd=Z1hUK2paQkZocG92WDJmUHZkTnZBZz09. Campus room: K-069. Accessibility Contact: hsbuild@uw.edu. Event Types: Lectures/Seminars. Event sponsors: Sponsored by the Department of Laboratory Medicine & Pathology. Target Audience: Faculty, fellows, post-docs, residents, and students. Tuesday, May 28, 2024, 4:00 PM – 5:00 PM.

Pathology Grand Rounds: Jonathan T.C. Liu, MD, PhD - Non-Destructive 3D Pathology and Analysis: A new perspective on cancer

Jonathan T.C. Liu, PhD, Professor; Mechanical Engineering, Bioengineering, and Laboratory Medicine & Pathology, Director, Molecular Biophotonics Laboratory, University of Washington,   Objectives:   State the advantages of 3D pathology over standard 2D histology. , Identify clinical use cases in which 3D pathology could add value. , Describe various approaches for AI-assisted analysis of 3D pathology datasets. Speaker disclosures:  Dr. Jonathan T.C. Liu has NOT had any financial relationships with any ineligible entities within the past 24 months. Why Attend? We are developing non-destructive slide-free 3D pathology methods for clinical decision support.  In comparison to conventional slide-based pathology, 3D pathology provides: (1) vastly greater sampling of tissue specimens including whole biopsies, (2) volumetric imaging of cell distributions and 3D tissue structures that are prognostic and predictive, and (3) a non-destructive and reversible workflow that preserves valuable biopsies for downstream… Event interval: Single day event. Campus location: UW Medical Center, Wing NE (UMNE). Online Meeting Link: https://washington.zoom.us/j/98387159855?pwd=bzhmRGNjWlM4YkZBYkdmQlluVko0Zz09. Campus room: NE-110k Pathology Conference Room. Accessibility Contact: hsbuild@uw.edu. Event Types: Lectures/Seminars. Target Audience: Faculty, fellows, post-docs, residents, and students. Wednesday, June 26, 2024, 1:30 PM – 2:30 PM. For more info visit dlmp.uw.edu.